Lamictal (Lamotrigine)

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Lamictal Dispersible/Chewable Tablet

Manufacturer: GSK

Country: Turkey

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Lamictal

Manufacturer: GSK

Country: Canada

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Lamictal Dispersible/Chewable Tablet

Manufacturer: GSK

Country: Turkey

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Lamictal Tablet

Manufacturer: GSK

Country: United Kingdom

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Lamictal

Manufacturer: GSK

Country: Canada

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Lamictal Dispersible/Chewable Tablet

Manufacturer: GSK

Country: Turkey

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Lamictal Tablet

Manufacturer: GSK

Country: United Kingdom

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Lamictal

Manufacturer: GSK

Country: Canada

Dosage: 150 mg

Qty-Price (USD):

Type:

Product: Lamictal Dispersible/Chewable Tablet

Manufacturer: GSK

Country: Turkey

Dosage: 200 mg

Qty-Price (USD):

Type:

Product: Lamictal Tablet

Manufacturer: GSK

Country: United Kingdom

Dosage: 200 mg

Qty-Price (USD):

Generic Equivalent of Lamictal

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Lamotrigine Dispersible Tablet

Manufacturer: Generic

Country: United Kingdom

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Lamotrigine

Manufacturer: Generic

Country: Canada

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Lamotrigine Dispersible Tablet

Manufacturer: Generic

Country: United Kingdom

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Lamotrigine

Manufacturer: Generic

Country: United Kingdom

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Lamotrigine

Manufacturer: Generic

Country: Canada

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Lamotrigine

Manufacturer: Generic

Country: Canada

Dosage: 150 mg

Qty-Price (USD):

Type:

Product: Lamotrigine

Manufacturer: Generic

Country: United States

Dosage: 150 mg

Qty-Price (USD):

Lamictal Information

medically reviewed by Carol Hou (BSc. Pharm) on June 23, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Lamictal and Lamotrigine at CanadaPharmacyOnline.com

The brand-name Lamictal (lamotrigine) is available in Canada, Turkey, and the United Kingdom by GSK.

Generic lamotrigine is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Lamotrigine:

Generic lamotrigine contains the same active ingredient as brand-name and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Lamictal. Studies have shown that generic lamotrigine is bioequivalent to brand-name Lamictal, meaning they have similar absorption rates and reach similar concentrations in the bloodstream. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/generic-drugs/generic-drug-facts

Dosage:

At this pharmacy, the brand Lamictal is available in oral tablets of 5 mg, 25 mg, 100 mg, 150 mg, and 200 mg, as well as dispersible/chewable tablets of 5 mg, 25 mg, 100 mg, and 200 mg.

Generic lamotrigine is available in 5 mg, 25 mg, 50 mg, 100 mg, 150 mg oral tablets, and 5 mg and 25 mg dispersible tablets.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Lamictal (lamotrigine) is primarily used to treat certain types of seizures in people with epilepsy, including partial seizures, tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Additionally, it is indicated for the maintenance treatment of bipolar I disorder in adults, helping to delay the occurrence of mood episodes such as mania, hypomania, and depression. In both conditions, lamotrigine is thought to work by stabilizing nerve activity in the brain.

Mechanism of Action:
Lamotrigine's primary mechanisms of action involve the use-dependent inhibition of voltage-gated sodium channels, stabilizing neuronal membranes and reducing excessive neuronal firing associated with seizures and mood disturbances. It is thought to reduce the presynaptic release of the excitatory neurotransmitter glutamate, likely due to its sodium channel-blocking effects. Additionally, lamotrigine inhibits specific voltage-gated calcium channels, particularly the N-type and T-type channels, which are believed to contribute to its therapeutic effects. It exhibits a weak inhibitory effect on the serotonin 5-HT3 receptor, and interactions with P/Q-type and R-type calcium channels are less definitively established.

Take Lamictal exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Lamictal, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects associated with Lamictal(lamotrigine). It is not an exhaustive list, and individual reactions can vary.

Common side effects - These are some common side effects of Lamictal, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning or if you experience any other concerning symptoms.
• Back pain
• Blurred vision or double vision
• Diarrhea
• Difficulty sleeping
• Dizziness
• Drowsiness or sleepiness
• Dry mouth
• Feeling tired
• Headache
• Lack of coordination
• Nausea or vomiting
• Runny or stuffy nose
• Sore throat
• Tremor or shaking
• Weight changes (both gain and loss have been reported)

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic Reactions: Symptoms can include hives, itching, swelling of the face, lips, tongue, or throat, and difficulty breathing.
• Aseptic Meningitis is inflammation of the membranes surrounding the brain and spinal cord, with symptoms like headache, fever, stiff neck, nausea, vomiting, confusion, and sensitivity to light.
• Blood Disorders: Such as unusual bruising or bleeding, pale skin, weakness, or frequent infections.
• Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): This is another severe reaction that can affect multiple organs.
• Hemophagocytic Lymphohistiocytosis (HLH): A rare but severe immune system reaction with symptoms like fever, swollen lymph nodes, and rash.
• Heart Problems: Including irregular heartbeat, fast or pounding heartbeats, chest pain, and shortness of breath.
• Liver Problems: Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, light-colored stools, and abdominal pain.
• Seizures: Worsening of seizures or new types of seizures (if taking lamotrigine for epilepsy), especially if the medication is stopped suddenly.
• Severe Skin Rash: This is a serious and potentially fatal side effect. Symptoms can include:
o Rash, which may be red or purple
o Blistering or peeling skin
o Hives
o Itching
o Painful sores in the mouth or around the eyes
o Fever
o Flu-like symptoms
o Swollen lymph nodes
• Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but very severe skin reactions.
• Suicidal Thoughts or Actions: Lamotrigine may increase the risk of suicidal thoughts or behavior in some people.

Long-Term Side Effects:
Some side effects may occur with long-term use of lamotrigine:
• Atypical Blood Cell Levels: Long-term use of lamotrigine can sometimes lead to decreases in white blood cell counts (neutropenia, leukopenia), red blood cell counts (anemia), or platelet counts (thrombocytopenia). These changes are usually not severe but require monitoring through blood tests as recommended by your doctor.
• Heart Rhythm Irregularities: Lamotrigine may increase the risk of certain heart rhythm problems, including PR prolongation and, in rare cases, more serious arrhythmias. This risk may be higher in individuals with pre-existing heart conditions or when used with interacting medications. ECG monitoring may be recommended in some cases, particularly when starting or increasing the dose or in patients with cardiac risk factors. Discuss any concerns with your doctor.
• Osteoporosis and Osteopenia: These conditions can increase the risk of bone fractures. Your doctor may perform tests to monitor your bone density.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Lamictal, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Lamictal should not be used if:
• You have been allergic to lamotrigine or any of its ingredients. This is a primary contraindication, as retaking the drug could cause another allergic reaction.
• You are taking dofetilide. This combination is contraindicated as lamotrigine can significantly increase the levels of dofetilide in your body, potentially leading to serious heart rhythm problems.
• In some regions, a history of Stevens-Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN) after previous use of lamotrigine might be considered an absolute contraindication.

Tell your doctor about your medical conditions, past and present, before starting Lamictal. This is crucial because certain conditions affect whether Lamictal is right for you. These conditions may include, but are not limited to:
• A history of severe rash with lamotrigine or other epilepsy medications. You may be at higher risk of developing a severe rash, including Stevens-Johnson syndrome or toxic epidermal necrolysis, which can be life-threatening.
• An autoimmune disease like lupus may be associated with an increased risk of specific side effects.
• Blood disorders, as Lamictal, can sometimes cause blood dyscrasias.
• Depression, mood problems, or suicidal thoughts or behavior. Lamictal may increase the risk of these, so close monitoring is essential.
• Heart problems, such as heart failure or irregular heart rhythm, as Lamictal may cause heart-related side effects.
• Kidney or liver problems, as these conditions can affect how your body processes and eliminates the drug, potentially leading to increased side effects. A lower dose may be necessary.
• Low levels of folic acid, as Lamictal can potentially interfere with folate metabolism in some individuals. While current clinical evidence does not indicate that lamotrigine causes a significant reduction in folate levels in most individuals, folic acid supplementation is often recommended, particularly for women of childbearing potential taking lamotrigine, to ensure adequate levels for fetal development and to mitigate any subtle effects on folate levels. Adequate folic acid intake is generally recommended for all women of childbearing age due to its role in preventing neural tube defects during pregnancy.

Drug Interactions:

Before taking Lamictal, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the Lamictal prescribing information.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also essential to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Lamictal. Lamictal may interact with other medicines, but is not limited to:

Significant Interactions (Generally Should Be Avoided):
• Dofetilide (Tikosyn): Taking lamotrigine with dofetilide can significantly increase the levels of dofetilide in your body, potentially leading to serious heart rhythm problems. This combination is usually contraindicated.

Moderate to Significant Interactions (Dose Adjustments or Monitoring May Be Needed):
• Acetaminophen (Tylenol): While acetaminophen might slightly affect how the body processes lamotrigine, this interaction is generally not considered clinically significant for most people using acetaminophen occasionally at recommended doses. However, individuals taking high doses of lamotrigine or those with liver problems should inform their doctor about their acetaminophen use, as monitoring might be considered in specific cases.
• Alprazolam (Xanax, Xanax XR): Combining lamotrigine with benzodiazepines like alprazolam can enhance the sedative effects of both drugs, potentially leading to increased drowsiness, dizziness, and impaired coordination. Caution and careful monitoring are advised if these medications are used together.
• Carbamazepine (Tegretol), Phenytoin (Dilantin), Phenobarbital, Primidone: These drugs can increase the metabolism of lamotrigine, leading to lower lamotrigine blood levels and potentially reduced effectiveness. Higher doses of lamotrigine may be needed.
• Certain HIV Medications (e.g., Lopinavir/ritonavir (Kaletra), Atazanavir (Reyataz) with Ritonavir (Norvir): These antiviral medications can lower lamotrigine blood levels, potentially reducing its effectiveness. Higher doses of lamotrigine might be required.
• Hormonal Contraceptives (including birth control pills, patches, and rings containing estrogen): Ethinyl estradiol, a common estrogen in many hormonal contraceptives, can decrease lamotrigine levels by about 50%. This can reduce the effectiveness of lamotrigine. Additionally, lamotrigine might affect the effectiveness of the contraceptive. Breakthrough bleeding might occur, indicating that the birth control may not be working correctly. Different types of contraception (non-hormonal or progestogen-only) might be recommended.
• Metformin (Fortamet, Glumetza): Lamotrigine can increase the levels of metformin in the body, potentially increasing the risk of metformin's side effects.
• Rifampin (Rifadin, Rimactane): This antibiotic can also significantly lower lamotrigine levels, potentially making it less effective. Dose adjustments of lamotrigine may be necessary if rifampin is taken concurrently.
• Tricyclic Antidepressants (e.g., Amitriptyline, Nortriptyline, Imipramine): Combining lamotrigine with tricyclic antidepressants may increase the risk of cardiac conduction abnormalities, such as PR prolongation. Careful consideration and ECG monitoring may be warranted, especially in individuals with pre-existing heart conditions.
• Valproic Acid (Depakote, Depakene): Valproic acid can significantly increase the blood levels of lamotrigine, increasing the risk of serious skin rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis. If these drugs are used together, a lower starting dose of lamotrigine and slower dose titration are usually necessary.

Other Potential Interactions:
• Drugs that cause drowsiness: Combining lamotrigine with other drugs that can cause drowsiness (such as alcohol, cannabis, antihistamines, sedatives, muscle relaxants, and opioid pain relievers) can increase this effect. • Orlistat (Alli, Xenical): While a significant interaction is not well-documented, orlistat, by reducing fat absorption, might theoretically interfere with the absorption of some medications if taken concurrently. It is advisable to separate the administration times of lamotrigine and orlistat to minimize any potential impact on lamotrigine absorption.

Alcohol
Concurrent use of alcohol with lamotrigine can exacerbate central nervous system depressant effects, potentially leading to increased dizziness, drowsiness, and impaired coordination. While the relationship between alcohol and seizures is complex and can vary, heavy or chronic alcohol use and alcohol withdrawal are more consistently associated with an increased risk of seizures in individuals with epilepsy. For those with bipolar disorder, alcohol can destabilize mood and potentially trigger mood episodes, counteracting the therapeutic effects of lamotrigine. Limiting or avoiding alcohol is generally recommended.

Caffeine
While caffeine does not directly affect lamotrigine's metabolism, its stimulant properties can worsen symptoms associated with bipolar disorder, such as agitation and insomnia. High caffeine intake might also potentially increase seizure susceptibility in some individuals with epilepsy. Moderation of caffeine consumption and discussion with a healthcare provider are advised, particularly for those with bipolar disorder or a history of seizures.

Ketogenic Diet
A ketogenic diet, characterized by very low carbohydrate and high fat intake, may decrease lamotrigine blood levels. This reduction could potentially diminish the effectiveness of lamotrigine in controlling seizures. If considering a ketogenic diet, close communication with your neurologist is essential for potential dose adjustments and monitoring of lamotrigine levels.

Pregnancy or Breastfeeding

Lamotrigine use during pregnancy is generally considered a safer option among antiepileptic drugs, but a slightly increased risk of oral clefts is debated. Continuous medication is vital, often requiring dosage adjustments and high-dose folic acid. During breastfeeding, lamotrigine passes into milk in small amounts and is usually acceptable, though infant monitoring for side effects is important. Consult your doctor if you are pregnant or breastfeeding.

Frequently Asked Questions about Lamictal at Canada Pharmacy Online:

Why is Lamictal more affordable in Canada than in the United States?

Prescription drug prices, including Lamictal, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

What is the difference between Lamictal 50 mg and 100 mg?

The dosage difference represents the different amounts of the same active ingredient (lamotrigine) present in each tablet.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Lamictal at once, per your doctor's prescription.

Can I buy over the counter from you?

No, Lamictal requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Lamictal?

Yes, there is a generic alternative for this product called lamotrigine.

What should I do if I miss a dose of Lamictal?

Take the missed dose as soon as you remember it, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss several doses, contact your doctor for guidance.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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